Connexin expression in CNS: Pathological significance and Lithium-mediated neuroprotection Doctorate thesis
نویسندگان
چکیده
.......................................................................................6 List of abbreviations........................................................................8 Introduction...................................................................................9 1.Gap junction................................................................................9 1.1.Connexins..................................................................................11 1.1.1 Gap Junnctions function...............................................................15 1.1.2.Functionl control of gap junction conductance......................................16 1.2. Pannexins...................................................................................19 1.2.1. Pannexins in CNS......................................................................22 1.3. Anatomical distribution of Gap Junction in the mammalian brain................23 Neurons..............................................................................................23 Astrocytes.............................................................................................25 Oligodendrocytes.....................................................................................26 Schwann cells...........................................................................................26 1.4. Gap Junction in Neuropathological conditions........................................27 1.4.1. Brain Ischemia..........................................................................28 1.4.2. Epilepsy...................................................................................28 1.4.3. Demyelinating syndromes..............................................................29 1.4.4. Neurodegenerative diseases.............................................................30 2. Lithium and neuroprotection............................................................31
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